Synonyms: Lethal osteogenesis imperfecta | OI type 2
A lethal type of osteogenesis imperfecta (OI) characterized by increased bone fragility low bone mass and susceptibility to bone fractures and presenting with multiple rib and long bone fractures at birth marked deformities broad long bones low density skull on X-ray and dark sclera.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Osteogenesis imperfecta type 2?
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Advocacy Organizations
Osteogenesis Imperfeca Foundation
The mission of the OI Foundation is to improve the quality of life for those living with osteogenesis imperfecta through research, education, awareness, and mutual support.
The Chandler Project
The Chandler Project brings awareness and shines a light on transformative research surrounding achondroplasia and other skeletal dysplasias by offering support to a global community and network of patients, parents, and caregivers seeking information on scientific discoveries, pharmaceutical advancements and surgical treatment options.
Wave of Support, Inc
Empowering those affected by bleeding disorders and other rare disease through advocacy, resources, education, and support
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Clinical Trials
For a list of clinical trials in this disease area, please click here.